meet our trainers
 Dr. Robert E. Zoubek Formycon, Germany Director Scientific Affairs & Client Relatioships |
 Prof. Michele Vendruscolo Department of Chemistry, University of Cambridge, UK |
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participants will learn about:
- Protein specific properties causing poor solubility or aggregation
- Extrinsic factors affecting aggregation
- Delivery systems in advanced development stages
At our Masterclass you will:
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predict protein solubility within in silico methods
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understand the viability of in silico compared with experimental results
- study the physico-chemical mechanisms of insolubility and aggregation
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learn about predictive experiments for solubility and aggregation
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explore formulation and delivery aspects - aiming to increase solubility
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gain insights into latest strategies to increase protein solubility and improve efficacy
Who should attend
Heads, senior directors, directors, senior managers, manager, scientists; Pharmaceutical & biotech professionals specializing in:
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Formulation
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Pre-Formulation
- Analytical Chemistry
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Preclinical / Analytical Development
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Drug Delivery
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Drug Discovery
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Toxicology
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Pharmaceutics
- Manufacturing Process
Solubility and aggregation of peptides and proteins determine their bioavailability and potential for immunogenicity. Therefore, the thorough understanding of solubility and aggregation mechanisms is the basis for a successful formulation development of biomolecules.
Next to peptide and protein intrinsic characteristics also extrinsic factor such as buffer, excipients but also process related impurities and primary packaging material influence the physical behaviour of biomolecules.
Media Partners
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